Thousands of reasons to Believe in Light
Real people. Real skin. Captured in real time.
We've helped thousands of customers achieve their skin goals.
Disclaimer - Individual results may vary. Healthy skin takes time—but your investment is risk-free with our 60-day money back guarantee.
Trusted by dermatologists and aesthetic experts
Photobiomodulation researcher — Harvard Medical School / Wellman Center for Photomedicine
I’ve spent years studying how red and near-infrared light interact with cells and tissues. Photobiomodulation research suggests that specific wavelengths can influence cellular signaling and biological processes involved in tissue repair and regeneration.
Dermatology & photobiomodulation researcher
LED light therapy has become an important area of dermatological research. My work has explored how specific wavelengths, including red and near-infrared light, interact with the skin and may influence processes such as collagen metabolism and skin rejuvenation.
Dermatologist — Brigham and Women’s Hospital / JAMA Dermatology
When we reviewed the evidence on at-home LED devices for acne, we found that red and blue light devices were associated with meaningful reductions in inflammatory and non-inflammatory acne lesions. The strongest improvements were generally seen after several weeks of consistent treatment.
Full Clinical Bibliography
Phototherapy with Blue (415 nm) and Red (660 nm) Light in the Treatment of Acne Vulgaris
P. Papageorgiou, A. Katsambas, A. Chu
British Journal of Dermatology. 2000;142(5):973–978
Acne Phototherapy with a High-Intensity, Enhanced, Narrow-Band, Blue Light Source: An Open Study and In Vitro Investigation
Akira Kawada, Yoshinori Aragane, Hiroko Kameyama, Yoshiko Sangen, Tadashi Tezuka
Journal of Dermatological Science. 2002;30(2):129–135
The Effective Treatment of Acne Vulgaris by a High-Intensity, Narrow Band 405–420 nm Light Source
Monica Elman, Michael Slatkine, Yoram Harth
Journal of Cosmetic and Laser Therapy. 2003;5(2):111–117
420 nm Intense Continuous Light Therapy for Acne
Tokuya Omi, Peter Bjerring, Shigeru Sato, Seiji Kawana, Raleigh W. Hankins, Mitsuyoshi Honda
Journal of Cosmetic and Laser Therapy. 2004;6(3):156–162
Blue Light Phototherapy in the Treatment of Acne
Tien-Yi Tzung, Kuan-Hsing Wu, Mei-Lun Huang
Photodermatology, Photoimmunology & Photomedicine. 2004;20(5):266–269
Phototherapy in the Treatment of Acne Vulgaris: What Is Its Role?
Aikaterini Charakida, Edward D. Seaton, Marietta Charakida, Paul Mouser, Antonias Avgerinos
American Journal of Clinical Dermatology. 2004;5(4):211–216
An Open Study to Determine the Efficacy of Blue Light in the Treatment of Mild to Moderate Acne
C. A. Morton, R. D. Scholefield, C. Whitehurst, J. Birch
Journal of Dermatological Treatment. 2005;16(4):219–223
Light-Emitting Diode 415 nm in the Treatment of Inflammatory Acne: An Open-Label, Multicentric, Pilot Investigation
J. F. Tremblay, D. J. Sire, N. J. Lowe, R. L. Moy
Journal of Cosmetic and Laser Therapy. 2006;8(1):31–33
Combination Blue (415 nm) and Red (633 nm) LED Phototherapy in the Treatment of Mild to Severe Acne Vulgaris
David J. Goldberg, Barbara A. Russell
Journal of Cosmetic and Laser Therapy. 2006;8(2):71–75
Blue and Red Light Combination LED Phototherapy for Acne Vulgaris in Patients with Skin Phototype IV
Seung Yoon Lee, Chung Eui You, Mi Youn Park
Lasers in Surgery and Medicine. 2007;39(2):180–188
Red Light Phototherapy Alone Is Effective for Acne Vulgaris: Randomized, Single-Blinded Clinical Trial
Jung Im Na, Dae Hun Suh
Dermatologic Surgery. 2007;33(10):1228–1233
Handheld LED Array Device in the Treatment of Acne Vulgaris
Neil S. Sadick
Journal of Drugs in Dermatology. 2008;7(4):347–350
An Assessment of the Efficacy of Blue Light Phototherapy in the Treatment of Acne Vulgaris
Sadia Ammad, Maria Gonzales, Chris Edwards, Andrew Y. Finlay, Caroline Mills
Journal of Cosmetic Dermatology. 2008;7(3):180–188
Phototherapy in the Treatment of Acne Vulgaris
Nevien A. Sami, Abeer T. Attia, Ashraf M. Badawi
Journal of Drugs in Dermatology. 2008;7(7):627–632
A Study to Determine the Effect of Combination Blue (415 nm) and Near-Infrared (830 nm) Light-Emitting Diode (LED) Therapy for Moderate Acne Vulgaris
Neil Sadick
Journal of Cosmetic and Laser Therapy. 2009;11(2):125–128
The Clinical and Histological Effect of Home-Use, Combination Blue-Red LED Phototherapy for Mild-to-Moderate Acne Vulgaris in Korean Patients: A Double-Blind, Randomized Controlled Trial
H. H. Kwon, J. B. Lee, J. Y. Yoon, S. Y. Park, H. H. Ryu, B. M. Park, Y. J. Kim, D. H. Suh
British Journal of Dermatology. 2013;168(5):1088–1094
Randomized Trial of Three Phototherapy Methods for the Treatment of Acne Vulgaris in Chinese Patients
Li-Hong Liu, Xin Fan, Yu-Xi An, Jin Zhang, Cong-Min Wang, Rong-Ya Yang
Photodermatology, Photoimmunology & Photomedicine. 2014;30(5):246–253
A Randomized Controlled Study for the Treatment of Acne Vulgaris Using High-Intensity 414 nm Solid State Diode Arrays
Caerwyn Ash, Anna Harrison, Samantha Drew, Rebecca Whittall
Journal of Cosmetic and Laser Therapy. 2015;17(4):170–176
Efficacy and Tolerability of a Combined 445 nm and 630 nm Over-the-Counter Light Therapy Mask with and without Topical Salicylic Acid versus Topical Benzoyl Peroxide for the Treatment of Mild-to-Moderate Acne Vulgaris
Mark S. Nestor, Nicole Swenson, Angela Macri, Mitchell Manway, Paige Paparone
Journal of Clinical and Aesthetic Dermatology. 2016;9(3):25–35
Light Therapies for Acne: Abridged Cochrane Systematic Review Including GRADE Assessments
J. Barbaric, R. Abbott, P. Posadzki, M. Car, L. H. Gunn, A. M. Layton, A. Majeed, J. Car
British Journal of Dermatology. 2018;178(1):61–75
A Comparative Study Between Once-Weekly and Alternating Twice-Weekly Regimen Using Blue (470 nm) and Red (640 nm) Light Combination LED Phototherapy for Moderate-to-Severe Acne Vulgaris
Sunatra Nitayavardhana, Woraphong Manuskiatti, Kathryn Anne G. Cembrano, Rungsima Wanitphakdeedecha
Lasers in Surgery and Medicine. 2021;53(8):1080–1085
Narrow Band Ultraviolet B Versus Red Light-Emitting Diodes in the Treatment of Facial Acne Vulgaris: A Randomized Controlled Trial
Marwa M. Eid, Marwa S. Saleh, Nesma M. Allam, Dalia M. Elsherbini, Walid Kamal Abdelbasset, Hadaya Mosaad Eladl
Photobiomodulation, Photomedicine, and Laser Surgery. 2021;39(6):418–424
Effect of Blue Light on Acne Vulgaris: A Systematic Review
Mara Lúcia Gonçalves Diogo, Thalita Molinos Campos, Elsa Susana Reis Fonseca, Christiane Pavani, Anna Carolina Ratto Tempestini Horliana, Kristianne Porta Santos Fernandes, Sandra Kalil Bussadori, Francisca Goreth Malheiro Moraes Fantin, Diego Portes Vieira Leite, Ângela Toshie Araki Yamamoto, Ricardo Scarparo Navarro, Lara Jansiski Motta
Sensors. 2021;21(20):6943
Comparison of Red Light and Blue Light Therapies for Mild-to-Moderate Acne Vulgaris: A Randomized Controlled Clinical Study
Jiahua Li, Jiandan Li, Linglin Zhang, Xiaojing Liu, Yajing Cao, Peiru Wang, Xiuli Wang
Photodermatology, Photoimmunology & Photomedicine. 2022;38(5):459–464
Utilization of Light-Emitting Diodes for Skin Therapy: Systematic Review and Meta-Analysis
Le Thi Nhu Ngoc, Ju-Young Moon, Young-Chul Lee
Photodermatology, Photoimmunology & Photomedicine. 2023;39(4):303–317
Visible Light in the Treatment of Acne Vulgaris
Edgar Akuffo-Addo, Kaitlyn Ramsay, Samiha Mohsen, Jeannie Boisvert, Ilya Mukovozov
Journal of Cutaneous Medicine and Surgery. 2024;28(6):567–571
At-Home LED Devices for the Treatment of Acne Vulgaris: A Systematic Review and Meta-Analysis
Sherry Ershadi, John S. Barbieri
JAMA Dermatology. 2025;161(5):552–555
Clinical Trial of a Novel Non-Thermal LED Array for Reversal of Photoaging: Clinical, Histologic, and Surface Profilometric Results
Robert A. Weiss, David H. McDaniel, Roy G. Geronemus, Margaret A. Weiss
Lasers in Surgery and Medicine. 2005;36(2):85–91
A Prospective, Randomized, Placebo-Controlled, Double-Blinded, and Split-Face Clinical Study on LED Phototherapy for Skin Rejuvenation: Clinical, Profilometric, Histologic, Ultrastructural, and Biochemical Evaluations and Comparison of Three Different Treatment Settings
Seung Yoon Lee, Ki-Ho Park, Jung-Woo Choi, Jung-Kyun Kwon, Doo Rak Lee, Mi Sun Shin, Jee Sung Lee, Chung Eui You, Mi Youn Park
Journal of Photochemistry and Photobiology B: Biology. 2007;88(1):51–67
Regulation of Skin Collagen Metabolism In Vitro Using a Pulsed 660-nm LED Light Source: Clinical Correlation with a Single-Blinded Study
Daniel Barolet, Charles J. Roberge, François A. Auger, Annie Boucher, Lucie Germain
Journal of Investigative Dermatology. 2009;129(12):2751–2759
A Controlled Trial to Determine the Efficacy of Red and Near-Infrared Light Treatment in Patient Satisfaction, Reduction of Fine Lines, Wrinkles, Skin Roughness, and Intradermal Collagen Density Increase
Alexander Wunsch, Karsten Matuschka
Photomedicine and Laser Surgery. 2014;32(2):93–100
The Efficacy and Safety of 660 nm and 411 to 777 nm Light-Emitting Devices for Treating Wrinkles
Chan Hee Nam, Byung Cheol Park, Myung Hwa Kim, Eun Hee Choi, Seung Phil Hong
Dermatologic Surgery. 2017;43(3):371–380
Efficacy of Home-Use Light-Emitting Diode Device at 637 and 854-nm for Facial Rejuvenation: A Split-Face Pilot Study
Janice Natasha C. Ng, Rungsima Wanitphakdeedecha, Chadakan Yan
Journal of Cosmetic Dermatology. 2020;19(9):2288–2294
The Use of a Light-Emitting Diode Device for Neck Rejuvenation and Its Safety on Thyroid Glands
Young In Lee, Eunjung Lee, Kee-Hyun Nam, Dong Yeob Shin, Jihee Kim, Jangmi Suk, Jin Young Kwak, Ju Hee Lee
Journal of Clinical Medicine. 2021;10(8):1774
Photobiomodulation Reduces Periocular Wrinkle Volume by 30%: A Randomized Controlled Trial
Lidiane Rocha Mota, Ivone da Silva Duarte, Thais Rodrigues Galache, Katia Maria dos Santos Pretti, Orlando Chiarelli Neto, Lara Jansiski Motta, Anna Carolina Ratto Tempestini Horliana, Daniela de Fátima Teixeira da Silva, Christiane Pavani
Photobiomodulation, Photomedicine, and Laser Surgery. 2023;41(2):48–56
Role of Photobiomodulation Application Frequency in Facial Rejuvenation: Randomized, Sham-Controlled, Double-Blind, Clinical Trial
Erick Frank Bragato, Adriana Fernandes Paisano, Christiane Pavani, Lara Jansiski Motta, Maria Lucia Zarvos Varellis, Marcela Chiedde, Gabriel Arruda da Silva, Sandra Kalil Bussadori, Raquel Agnelli Mesquita-Ferrari, Kristianne Porta Santos Fernandes
Lasers in Medical Science. 2025;40(1):170
Clinical Study to Evaluate the Efficacy and Safety of Home-Used LED and IRED Mask for Crow’s Feet: A Multi-Center, Randomized, Double-Blind, Sham-Controlled Study
Sang Hyun Park, Seong Oh Park, Jae-A Jung
Medicine. 2025;104(7):e41596
Efficacy and Safety of 570/590 nm Yellow Light Combined with Red Light and Infrared LED in Treating Facial Skin Photoaging: A Single-Center, Randomized Controlled, Exploratory Study
Shiyun Yi, Jie Ding, Xihao Li, Xing Guo, Hongxuan Wu, Xianwei Cao, Duyang Wang, Zhibin Zhang
Lasers in Medical Science. 2025;40(1):435
Continuous Irradiation with a 633-nm Light-Emitting Diode Exerts an Anti-Aging Effect on Human Skin Cells
Hak Sun Kim, Won Sang Park, Jong-In Baek, Bo-Sub Lee, Dae Sung Yoo, Si Jun Park
International Journal of Molecular Medicine. 2015;35(2):383–390
Skin Photorejuvenation Effects of Light-Emitting Diodes (LEDs): A Comparative Study of Yellow and Red LEDs In Vitro and In Vivo
S. K. Kim, H. R. You, S. H. Kim, S. J. Yun, S. C. Lee, J. B. Lee
Clinical and Experimental Dermatology. 2016;41(7):798–805
Light-Emitting Diodes in Dermatology: A Systematic Review of Randomized Controlled Trials
Jared Jagdeo, Evan Austin, Andrew Mamalis, et al.
Lasers in Surgery and Medicine. 2018;50(6):613–628
Light Emitting Diode Phototherapy for Skin Aging
Alisen Huang, Julie K. Nguyen, Derek Ho, Jared Jagdeo
Journal of Drugs in Dermatology. 2020;19(4):359–364
Photobiomodulation: A Review of the Molecular Evidence for Low Level Light Therapy
Graeme Ewan Glass
Journal of Plastic, Reconstructive & Aesthetic Surgery. 2021;74(5):1050–1060
Utilization of Light-Emitting Diodes for Skin Therapy: Systematic Review and Meta-Analysis
Le Thi Nhu Ngoc, Ju-Young Moon, Young-Chul Lee
Photodermatology, Photoimmunology & Photomedicine. 2023;39(4):303–317
Photobiomodulation: A Systematic Review of the Oncologic Safety of Low-Level Light Therapy for Aesthetic Skin Rejuvenation
Graeme Ewan Glass
Aesthetic Surgery Journal. 2023;43(5):NP357–NP371
Evidence-Based Consensus on the Clinical Application of Photobiomodulation
Jalal Maghfour, Jessica Mineroff, David M. Ozog, Jared Jagdeo, Henry W. Lim, Indermeet Kohli, Rox Anderson, Kristen M. Kelly, Andrew Mamalis, Gilly Munavalli, Ferraresi Cleber, Daniel Siegel, Ivayla Geneva, Robert Weiss, Akimich Morita, Anders Juanita, Mitchel P. Goldman, Paraveen R. Arany, David Sliney, Omar A. Ibrahimi, Michael Chopp, Samia Esmat, John Tuner
Journal of the American Academy of Dermatology. 2025;93(2):429–443
The Application of Light Emitting Diode (LED) in Cosmetic Dermatology
Ziwei Guo, Kaihua Yuan
Photodermatology, Photoimmunology & Photomedicine. 2025;41(5):e70041
Red Light-Emitting Diode (LED) Therapy Accelerates Wound Healing Post-Blepharoplasty and Periocular Laser Ablative Resurfacing
David H. McDaniel, Robert A. Weiss, Roy G. Geronemus, et al.
Lasers in Surgery and Medicine. 2006;38(9):865–871
Combined Visible Light and Infrared Light-Emitting Diode (LED) Therapy Enhances Wound Healing After Laser Ablative Resurfacing of Photodamaged Facial Skin
M. A. Trelles, I. Allones, E. Mayo
Medical Laser Application. 2006;21(3):165–175
Use of Light-Emitting Diode Photomodulation to Reduce Erythema and Discomfort After Intense Pulsed Light Treatment of Photodamage
Jane G. Khoury, Mitchel P. Goldman
Journal of Cosmetic Dermatology. 2008;7(1):30–34
Improvement of Postfractional Laser Erythema with Light-Emitting Diode Photomodulation
Tina S. Alster, Rungsima Wanitphakdeedecha
Dermatologic Surgery. 2009;35(5):813–815
Phototherapy Promotes Healing of Chronic Diabetic Leg Ulcers That Failed to Respond to Other Therapies
Debora G. Minatel, Marco Andrey C. Frade, Suzelei C. França, Chukuka S. Enwemeka
Lasers in Surgery and Medicine. 2009;41(6):433–441
LED Phototherapy Improves Healing of Nipple Trauma: A Pilot Study
Maria Emília de Abreu Chaves, Angélica Rodrigues de Araújo, Suellen Fonseca Santos, Marcos Pinotti, Leandro Soares Oliveira
Photomedicine and Laser Surgery. 2012;30(3):172–178
830 nm Light-Emitting Diode Low Level Light Therapy (LED-LLLT) Enhances Wound Healing: A Preliminary Study
Pok Kee Min, Boncheol Leo Goo
Laser Therapy. 2013;22(1):43–49
Effects of Low-Power Light Therapy on Wound Healing: LASER x LED
Maria Emília de Abreu Chaves, Angélica Rodrigues de Araújo, André Costa Cruz Piancastelli, Marcos Pinotti
Anais Brasileiros de Dermatologia. 2014;89(4):616–623
Phototherapy with LED Shows Promising Results in Healing Chronic Wounds in Diabetes Mellitus Patients: A Prospective Randomized Double-Blind Study
Igor Frangež, Tea Nizič-Kos, Helena Ban Frangež
Photomedicine and Laser Surgery. 2018;36(7):380–386
Blinded, Randomized, Controlled Trial Evaluating the Effects of Light-Emitting Diode Photomodulation on Lower Extremity Wounds Left to Heal by Secondary Intention
Marina Perper, Ariel Eber, Scott F. Lindsey, Keyvan Nouri
Dermatologic Surgery. 2020;46(5):605–611
Local and Systemic Effects of Low-Level Light Therapy with Light-Emitting Diodes to Improve Erythema After Fractional Ablative Skin Resurfacing: A Controlled Study
Rungsima Wanitphakdeedecha, et al.
Lasers in Medical Science. 2019;34:1599–1607
The Role of Light Emitting Diode in Wound Healing: A Systematic Review of Experimental Studies
Rebeca Barbosa da Rocha, Dakson Douglas Araújo, Fabrício Dos Santos Machado, Vinicius Saura Cardoso, Ana Jérsia Araújo, José Delano Barreto Marinho-Filho
Cell Biochemistry and Function. 2024;42(5):e4086
Modulation of Gene Expression in Skin Wound Healing by Photobiomodulation Therapy: A Systematic Review In Vivo Studies
Pilar, et al.
Photodermatology, Photoimmunology & Photomedicine. 2024;40(4):e12990
Photobiomodulation in Burn Wounds: A Systematic Review and Meta-Analysis of Clinical and Preclinical Studies
Lilian de Araujo Pradal, Edicleia de Freitas, Marcia Rosangela Buzanello Azevedo, Rosemeire Costa, Gladson Ricardo Flor Bertolini
Photobiomodulation, Photomedicine, and Laser Surgery. 2025;43(1):8–23
Dose-Response and Efficacy of 660-Nanometer Low-Level Laser Therapy in Healing Diabetic Foot Ulcers: A Randomized, Double-Blind, Clinical Trial
Mariana Bezerra Miranda, Ana Carolina Silva Barros, Lorena Veloso Coelho, et al.
Lasers in Medical Science. 2025;40(1):399
Clinical Dosimetry and Efficacy of LED Photobiomodulation for Chronic Lower-Limb Wound Healing: A Systematic Review of Randomized Trials
Mariana Bezerra Miranda, Ana Carolina Silva Barros, Ana Vitoria Lima de Paula, Rayana Fontenele Alves, Rebeca Barbosa da Rocha, Vinicius Saura Cardoso
Lasers in Medical Science. 2026;41(1):117
Qualitative Comparison of LED and LASER Effects on Cutaneous Wound Healing: A Systematic Review of Experimental Studies
Mariana Bezerra Miranda, et al.
Cell Biochemistry and Function. 2026;44(1):e70161
The Healing Effect of Photobiomodulation on Venous Leg Ulcers: A Systematic Review and Meta-Analysis
Aqella Rasul, Frederik Plum, Katrine Elisabeth Karmisholt, Klaus Kirketerp-Møller
Wound Repair and Regeneration. 2026;34(2):e70144
Phototherapy with Blue (415 nm) and Red (660 nm) Light in the Treatment of Acne Vulgaris
P. Papageorgiou, A. Katsambas, A. Chu
British Journal of Dermatology. 2000;142(5):973–978
Acne Phototherapy with a High-Intensity, Enhanced, Narrow-Band, Blue Light Source: An Open Study and In Vitro Investigation
Akira Kawada, Yoshinori Aragane, Hiroko Kameyama, Yoshiko Sangen, Tadashi Tezuka
Journal of Dermatological Science. 2002;30(2):129–135
The Effective Treatment of Acne Vulgaris by a High-Intensity, Narrow Band 405–420 nm Light Source
Monica Elman, Michael Slatkine, Yoram Harth
Journal of Cosmetic and Laser Therapy. 2003;5(2):111–117
420 nm Intense Continuous Light Therapy for Acne
Tokuya Omi, Peter Bjerring, Shigeru Sato, Seiji Kawana, Raleigh W. Hankins, Mitsuyoshi Honda
Journal of Cosmetic and Laser Therapy. 2004;6(3):156–162
Blue Light Phototherapy in the Treatment of Acne
Tien-Yi Tzung, Kuan-Hsing Wu, Mei-Lun Huang
Photodermatology, Photoimmunology & Photomedicine. 2004;20(5):266–269
Phototherapy in the Treatment of Acne Vulgaris: What Is Its Role?
Aikaterini Charakida, Edward D. Seaton, Marietta Charakida, Paul Mouser, Antonias Avgerinos
American Journal of Clinical Dermatology. 2004;5(4):211–216
An Open Study to Determine the Efficacy of Blue Light in the Treatment of Mild to Moderate Acne
C. A. Morton, R. D. Scholefield, C. Whitehurst, J. Birch
Journal of Dermatological Treatment. 2005;16(4):219–223
Light-Emitting Diode 415 nm in the Treatment of Inflammatory Acne: An Open-Label, Multicentric, Pilot Investigation
J. F. Tremblay, D. J. Sire, N. J. Lowe, R. L. Moy
Journal of Cosmetic and Laser Therapy. 2006;8(1):31–33
Combination Blue (415 nm) and Red (633 nm) LED Phototherapy in the Treatment of Mild to Severe Acne Vulgaris
David J. Goldberg, Barbara A. Russell
Journal of Cosmetic and Laser Therapy. 2006;8(2):71–75
Blue and Red Light Combination LED Phototherapy for Acne Vulgaris in Patients with Skin Phototype IV
Seung Yoon Lee, Chung Eui You, Mi Youn Park
Lasers in Surgery and Medicine. 2007;39(2):180–188
Red Light Phototherapy Alone Is Effective for Acne Vulgaris: Randomized, Single-Blinded Clinical Trial
Jung Im Na, Dae Hun Suh
Dermatologic Surgery. 2007;33(10):1228–1233
Handheld LED Array Device in the Treatment of Acne Vulgaris
Neil S. Sadick
Journal of Drugs in Dermatology. 2008;7(4):347–350
An Assessment of the Efficacy of Blue Light Phototherapy in the Treatment of Acne Vulgaris
Sadia Ammad, Maria Gonzales, Chris Edwards, Andrew Y. Finlay, Caroline Mills
Journal of Cosmetic Dermatology. 2008;7(3):180–188
Phototherapy in the Treatment of Acne Vulgaris
Nevien A. Sami, Abeer T. Attia, Ashraf M. Badawi
Journal of Drugs in Dermatology. 2008;7(7):627–632
A Study to Determine the Effect of Combination Blue (415 nm) and Near-Infrared (830 nm) Light-Emitting Diode (LED) Therapy for Moderate Acne Vulgaris
Neil Sadick
Journal of Cosmetic and Laser Therapy. 2009;11(2):125–128
The Clinical and Histological Effect of Home-Use, Combination Blue-Red LED Phototherapy for Mild-to-Moderate Acne Vulgaris in Korean Patients: A Double-Blind, Randomized Controlled Trial
H. H. Kwon, J. B. Lee, J. Y. Yoon, S. Y. Park, H. H. Ryu, B. M. Park, Y. J. Kim, D. H. Suh
British Journal of Dermatology. 2013;168(5):1088–1094
Randomized Trial of Three Phototherapy Methods for the Treatment of Acne Vulgaris in Chinese Patients
Li-Hong Liu, Xin Fan, Yu-Xi An, Jin Zhang, Cong-Min Wang, Rong-Ya Yang
Photodermatology, Photoimmunology & Photomedicine. 2014;30(5):246–253
A Randomized Controlled Study for the Treatment of Acne Vulgaris Using High-Intensity 414 nm Solid State Diode Arrays
Caerwyn Ash, Anna Harrison, Samantha Drew, Rebecca Whittall
Journal of Cosmetic and Laser Therapy. 2015;17(4):170–176
Efficacy and Tolerability of a Combined 445 nm and 630 nm Over-the-Counter Light Therapy Mask with and without Topical Salicylic Acid versus Topical Benzoyl Peroxide for the Treatment of Mild-to-Moderate Acne Vulgaris
Mark S. Nestor, Nicole Swenson, Angela Macri, Mitchell Manway, Paige Paparone
Journal of Clinical and Aesthetic Dermatology. 2016;9(3):25–35
Light Therapies for Acne: Abridged Cochrane Systematic Review Including GRADE Assessments
J. Barbaric, R. Abbott, P. Posadzki, M. Car, L. H. Gunn, A. M. Layton, A. Majeed, J. Car
British Journal of Dermatology. 2018;178(1):61–75
A Comparative Study Between Once-Weekly and Alternating Twice-Weekly Regimen Using Blue (470 nm) and Red (640 nm) Light Combination LED Phototherapy for Moderate-to-Severe Acne Vulgaris
Sunatra Nitayavardhana, Woraphong Manuskiatti, Kathryn Anne G. Cembrano, Rungsima Wanitphakdeedecha
Lasers in Surgery and Medicine. 2021;53(8):1080–1085
Narrow Band Ultraviolet B Versus Red Light-Emitting Diodes in the Treatment of Facial Acne Vulgaris: A Randomized Controlled Trial
Marwa M. Eid, Marwa S. Saleh, Nesma M. Allam, Dalia M. Elsherbini, Walid Kamal Abdelbasset, Hadaya Mosaad Eladl
Photobiomodulation, Photomedicine, and Laser Surgery. 2021;39(6):418–424
Effect of Blue Light on Acne Vulgaris: A Systematic Review
Mara Lúcia Gonçalves Diogo, Thalita Molinos Campos, Elsa Susana Reis Fonseca, Christiane Pavani, Anna Carolina Ratto Tempestini Horliana, Kristianne Porta Santos Fernandes, Sandra Kalil Bussadori, Francisca Goreth Malheiro Moraes Fantin, Diego Portes Vieira Leite, Ângela Toshie Araki Yamamoto, Ricardo Scarparo Navarro, Lara Jansiski Motta
Sensors. 2021;21(20):6943
Comparison of Red Light and Blue Light Therapies for Mild-to-Moderate Acne Vulgaris: A Randomized Controlled Clinical Study
Jiahua Li, Jiandan Li, Linglin Zhang, Xiaojing Liu, Yajing Cao, Peiru Wang, Xiuli Wang
Photodermatology, Photoimmunology & Photomedicine. 2022;38(5):459–464
Utilization of Light-Emitting Diodes for Skin Therapy: Systematic Review and Meta-Analysis
Le Thi Nhu Ngoc, Ju-Young Moon, Young-Chul Lee
Photodermatology, Photoimmunology & Photomedicine. 2023;39(4):303–317
Visible Light in the Treatment of Acne Vulgaris
Edgar Akuffo-Addo, Kaitlyn Ramsay, Samiha Mohsen, Jeannie Boisvert, Ilya Mukovozov
Journal of Cutaneous Medicine and Surgery. 2024;28(6):567–571
At-Home LED Devices for the Treatment of Acne Vulgaris: A Systematic Review and Meta-Analysis
Sherry Ershadi, John S. Barbieri
JAMA Dermatology. 2025;161(5):552–555
Clinical Trial of a Novel Non-Thermal LED Array for Reversal of Photoaging: Clinical, Histologic, and Surface Profilometric Results
Robert A. Weiss, David H. McDaniel, Roy G. Geronemus, Margaret A. Weiss
Lasers in Surgery and Medicine. 2005;36(2):85–91
A Prospective, Randomized, Placebo-Controlled, Double-Blinded, and Split-Face Clinical Study on LED Phototherapy for Skin Rejuvenation: Clinical, Profilometric, Histologic, Ultrastructural, and Biochemical Evaluations and Comparison of Three Different Treatment Settings
Seung Yoon Lee, Ki-Ho Park, Jung-Woo Choi, Jung-Kyun Kwon, Doo Rak Lee, Mi Sun Shin, Jee Sung Lee, Chung Eui You, Mi Youn Park
Journal of Photochemistry and Photobiology B: Biology. 2007;88(1):51–67
Regulation of Skin Collagen Metabolism In Vitro Using a Pulsed 660-nm LED Light Source: Clinical Correlation with a Single-Blinded Study
Daniel Barolet, Charles J. Roberge, François A. Auger, Annie Boucher, Lucie Germain
Journal of Investigative Dermatology. 2009;129(12):2751–2759
A Controlled Trial to Determine the Efficacy of Red and Near-Infrared Light Treatment in Patient Satisfaction, Reduction of Fine Lines, Wrinkles, Skin Roughness, and Intradermal Collagen Density Increase
Alexander Wunsch, Karsten Matuschka
Photomedicine and Laser Surgery. 2014;32(2):93–100
The Efficacy and Safety of 660 nm and 411 to 777 nm Light-Emitting Devices for Treating Wrinkles
Chan Hee Nam, Byung Cheol Park, Myung Hwa Kim, Eun Hee Choi, Seung Phil Hong
Dermatologic Surgery. 2017;43(3):371–380
Efficacy of Home-Use Light-Emitting Diode Device at 637 and 854-nm for Facial Rejuvenation: A Split-Face Pilot Study
Janice Natasha C. Ng, Rungsima Wanitphakdeedecha, Chadakan Yan
Journal of Cosmetic Dermatology. 2020;19(9):2288–2294
The Use of a Light-Emitting Diode Device for Neck Rejuvenation and Its Safety on Thyroid Glands
Young In Lee, Eunjung Lee, Kee-Hyun Nam, Dong Yeob Shin, Jihee Kim, Jangmi Suk, Jin Young Kwak, Ju Hee Lee
Journal of Clinical Medicine. 2021;10(8):1774
Photobiomodulation Reduces Periocular Wrinkle Volume by 30%: A Randomized Controlled Trial
Lidiane Rocha Mota, Ivone da Silva Duarte, Thais Rodrigues Galache, Katia Maria dos Santos Pretti, Orlando Chiarelli Neto, Lara Jansiski Motta, Anna Carolina Ratto Tempestini Horliana, Daniela de Fátima Teixeira da Silva, Christiane Pavani
Photobiomodulation, Photomedicine, and Laser Surgery. 2023;41(2):48–56
Role of Photobiomodulation Application Frequency in Facial Rejuvenation: Randomized, Sham-Controlled, Double-Blind, Clinical Trial
Erick Frank Bragato, Adriana Fernandes Paisano, Christiane Pavani, Lara Jansiski Motta, Maria Lucia Zarvos Varellis, Marcela Chiedde, Gabriel Arruda da Silva, Sandra Kalil Bussadori, Raquel Agnelli Mesquita-Ferrari, Kristianne Porta Santos Fernandes
Lasers in Medical Science. 2025;40(1):170
Clinical Study to Evaluate the Efficacy and Safety of Home-Used LED and IRED Mask for Crow’s Feet: A Multi-Center, Randomized, Double-Blind, Sham-Controlled Study
Sang Hyun Park, Seong Oh Park, Jae-A Jung
Medicine. 2025;104(7):e41596
Efficacy and Safety of 570/590 nm Yellow Light Combined with Red Light and Infrared LED in Treating Facial Skin Photoaging: A Single-Center, Randomized Controlled, Exploratory Study
Shiyun Yi, Jie Ding, Xihao Li, Xing Guo, Hongxuan Wu, Xianwei Cao, Duyang Wang, Zhibin Zhang
Lasers in Medical Science. 2025;40(1):435
Continuous Irradiation with a 633-nm Light-Emitting Diode Exerts an Anti-Aging Effect on Human Skin Cells
Hak Sun Kim, Won Sang Park, Jong-In Baek, Bo-Sub Lee, Dae Sung Yoo, Si Jun Park
International Journal of Molecular Medicine. 2015;35(2):383–390
Skin Photorejuvenation Effects of Light-Emitting Diodes (LEDs): A Comparative Study of Yellow and Red LEDs In Vitro and In Vivo
S. K. Kim, H. R. You, S. H. Kim, S. J. Yun, S. C. Lee, J. B. Lee
Clinical and Experimental Dermatology. 2016;41(7):798–805
Light-Emitting Diodes in Dermatology: A Systematic Review of Randomized Controlled Trials
Jared Jagdeo, Evan Austin, Andrew Mamalis, et al.
Lasers in Surgery and Medicine. 2018;50(6):613–628
Light Emitting Diode Phototherapy for Skin Aging
Alisen Huang, Julie K. Nguyen, Derek Ho, Jared Jagdeo
Journal of Drugs in Dermatology. 2020;19(4):359–364
Photobiomodulation: A Review of the Molecular Evidence for Low Level Light Therapy
Graeme Ewan Glass
Journal of Plastic, Reconstructive & Aesthetic Surgery. 2021;74(5):1050–1060
Utilization of Light-Emitting Diodes for Skin Therapy: Systematic Review and Meta-Analysis
Le Thi Nhu Ngoc, Ju-Young Moon, Young-Chul Lee
Photodermatology, Photoimmunology & Photomedicine. 2023;39(4):303–317
Photobiomodulation: A Systematic Review of the Oncologic Safety of Low-Level Light Therapy for Aesthetic Skin Rejuvenation
Graeme Ewan Glass
Aesthetic Surgery Journal. 2023;43(5):NP357–NP371
Evidence-Based Consensus on the Clinical Application of Photobiomodulation
Jalal Maghfour, Jessica Mineroff, David M. Ozog, Jared Jagdeo, Henry W. Lim, Indermeet Kohli, Rox Anderson, Kristen M. Kelly, Andrew Mamalis, Gilly Munavalli, Ferraresi Cleber, Daniel Siegel, Ivayla Geneva, Robert Weiss, Akimich Morita, Anders Juanita, Mitchel P. Goldman, Paraveen R. Arany, David Sliney, Omar A. Ibrahimi, Michael Chopp, Samia Esmat, John Tuner
Journal of the American Academy of Dermatology. 2025;93(2):429–443
The Application of Light Emitting Diode (LED) in Cosmetic Dermatology
Ziwei Guo, Kaihua Yuan
Photodermatology, Photoimmunology & Photomedicine. 2025;41(5):e70041
Red Light-Emitting Diode (LED) Therapy Accelerates Wound Healing Post-Blepharoplasty and Periocular Laser Ablative Resurfacing
David H. McDaniel, Robert A. Weiss, Roy G. Geronemus, et al.
Lasers in Surgery and Medicine. 2006;38(9):865–871
Combined Visible Light and Infrared Light-Emitting Diode (LED) Therapy Enhances Wound Healing After Laser Ablative Resurfacing of Photodamaged Facial Skin
M. A. Trelles, I. Allones, E. Mayo
Medical Laser Application. 2006;21(3):165–175
Use of Light-Emitting Diode Photomodulation to Reduce Erythema and Discomfort After Intense Pulsed Light Treatment of Photodamage
Jane G. Khoury, Mitchel P. Goldman
Journal of Cosmetic Dermatology. 2008;7(1):30–34
Improvement of Postfractional Laser Erythema with Light-Emitting Diode Photomodulation
Tina S. Alster, Rungsima Wanitphakdeedecha
Dermatologic Surgery. 2009;35(5):813–815
Phototherapy Promotes Healing of Chronic Diabetic Leg Ulcers That Failed to Respond to Other Therapies
Debora G. Minatel, Marco Andrey C. Frade, Suzelei C. França, Chukuka S. Enwemeka
Lasers in Surgery and Medicine. 2009;41(6):433–441
LED Phototherapy Improves Healing of Nipple Trauma: A Pilot Study
Maria Emília de Abreu Chaves, Angélica Rodrigues de Araújo, Suellen Fonseca Santos, Marcos Pinotti, Leandro Soares Oliveira
Photomedicine and Laser Surgery. 2012;30(3):172–178
830 nm Light-Emitting Diode Low Level Light Therapy (LED-LLLT) Enhances Wound Healing: A Preliminary Study
Pok Kee Min, Boncheol Leo Goo
Laser Therapy. 2013;22(1):43–49
Effects of Low-Power Light Therapy on Wound Healing: LASER x LED
Maria Emília de Abreu Chaves, Angélica Rodrigues de Araújo, André Costa Cruz Piancastelli, Marcos Pinotti
Anais Brasileiros de Dermatologia. 2014;89(4):616–623
Phototherapy with LED Shows Promising Results in Healing Chronic Wounds in Diabetes Mellitus Patients: A Prospective Randomized Double-Blind Study
Igor Frangež, Tea Nizič-Kos, Helena Ban Frangež
Photomedicine and Laser Surgery. 2018;36(7):380–386
Blinded, Randomized, Controlled Trial Evaluating the Effects of Light-Emitting Diode Photomodulation on Lower Extremity Wounds Left to Heal by Secondary Intention
Marina Perper, Ariel Eber, Scott F. Lindsey, Keyvan Nouri
Dermatologic Surgery. 2020;46(5):605–611
Local and Systemic Effects of Low-Level Light Therapy with Light-Emitting Diodes to Improve Erythema After Fractional Ablative Skin Resurfacing: A Controlled Study
Rungsima Wanitphakdeedecha, et al.
Lasers in Medical Science. 2019;34:1599–1607
The Role of Light Emitting Diode in Wound Healing: A Systematic Review of Experimental Studies
Rebeca Barbosa da Rocha, Dakson Douglas Araújo, Fabrício Dos Santos Machado, Vinicius Saura Cardoso, Ana Jérsia Araújo, José Delano Barreto Marinho-Filho
Cell Biochemistry and Function. 2024;42(5):e4086
Modulation of Gene Expression in Skin Wound Healing by Photobiomodulation Therapy: A Systematic Review In Vivo Studies
Pilar, et al.
Photodermatology, Photoimmunology & Photomedicine. 2024;40(4):e12990
Photobiomodulation in Burn Wounds: A Systematic Review and Meta-Analysis of Clinical and Preclinical Studies
Lilian de Araujo Pradal, Edicleia de Freitas, Marcia Rosangela Buzanello Azevedo, Rosemeire Costa, Gladson Ricardo Flor Bertolini
Photobiomodulation, Photomedicine, and Laser Surgery. 2025;43(1):8–23
Dose-Response and Efficacy of 660-Nanometer Low-Level Laser Therapy in Healing Diabetic Foot Ulcers: A Randomized, Double-Blind, Clinical Trial
Mariana Bezerra Miranda, Ana Carolina Silva Barros, Lorena Veloso Coelho, et al.
Lasers in Medical Science. 2025;40(1):399
Clinical Dosimetry and Efficacy of LED Photobiomodulation for Chronic Lower-Limb Wound Healing: A Systematic Review of Randomized Trials
Mariana Bezerra Miranda, Ana Carolina Silva Barros, Ana Vitoria Lima de Paula, Rayana Fontenele Alves, Rebeca Barbosa da Rocha, Vinicius Saura Cardoso
Lasers in Medical Science. 2026;41(1):117
Qualitative Comparison of LED and LASER Effects on Cutaneous Wound Healing: A Systematic Review of Experimental Studies
Mariana Bezerra Miranda, et al.
Cell Biochemistry and Function. 2026;44(1):e70161
The Healing Effect of Photobiomodulation on Venous Leg Ulcers: A Systematic Review and Meta-Analysis
Aqella Rasul, Frederik Plum, Katrine Elisabeth Karmisholt, Klaus Kirketerp-Møller
Wound Repair and Regeneration. 2026;34(2):e70144
